PATHOLOGY VISIONS 2014 PRESENTER
Abstract: Optical coherence tomography (OCT) permits rapid non-destructive tissue imaging that resembles whole slide images (WSIs), which means that pathologists should be well-equipped to use OCT clinically. OCT and related techniques allow not only rapid specimen (i.e. ex vivo) imaging, but also in vivo imaging of patients. Intra-operative style endometrial cancer assessment is a possible early application, due to good natural contrast between glands, stroma and myometrium in OCT images. Breast imaging is also of interest for a variety of reasons related to specimen volume, actively evolving clinical practice and difficulty in freezing, among other reasons. This talk will introduce the concept of specimen OCT in a pathologist-friendly fashion, and will then cover recent and ongoing work in our lab. The chief goal of the current projects is to generate pilot data that can be used to justify prospective study of clinical applications (e.g., endometrial cancer depth of invasion assessment, breast margins assessment, sentinel lymph node studies, etc.). Beyond ex-vivo applications, OCT-based histopathology experience should lead directly to in-vivo clinical applications. Given that other medical specialties are actively working on similar imaging techniques, it is vital for pathologists to fully investigate and possibly develop clinical applications based on OCT and other advanced imaging technologies.