With the increasing implementation of digital cytology much interest has been generated in the application of artificial intelligence (AI) algorithms to cytology. While cytology has been early adopters of AI for screening cervical cytology specimens the field has been slower to adopt AI for non-GYN specimens. The introduction of whole slide imaging (WSI) to non-GYN cytology has created an opportunity for AI algorithms. The American Society of Cytopathology (ASC) along with the International Academy of Cytology and the Digital Pathology Association convened a task force to investigate digital cytology and AI applications. In this ASC companion session two experts from the task force will review the history of AI in cytology, present the current state of AI in cytology, and discuss what opportunities lie ahead for AI in cytology.